Optically active amine derivatives and preparation process therefor
US7026515B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Nov 9, 2001 |
| Grant date | Apr 11, 2006 |
| Priority date | — |
| Expiry date | Apr 1, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A readily available and inexpensive natural α-amino acid is converted into a compound represented by formula (1), which is then reacted with an organometallic reagent represented by formula (2) to give an optically active 5-hydroxyoxazolidine represented by formula (3), which is then treated with an acid to provide an optically active aminoketone represented by formula (4). The product is then converted into an optically active aminoalcohol represented by formula (5) or (6) by, for example reduction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.