Apparatus and method for non-invasive spectroscopic measurement of analytes in tissue using a matched reference analyte

US7027848B2 · kind B2 · utility

Assignees

• InLight Solutions, Inc. · US
• The Regents of the University of New Mexico · US

Inventors

• Mark Ries Robinson · Albuquerque, US
• Cliona Fleming · Albuquerque, US
• Howland Jones · Rio Rancho, US
• Mark Rohrscheib · Albuquerque, US

Key dates

• Filing date: Apr 4, 2002
• Grant date: Apr 11, 2006
• Expiry date: Apr 7, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/1495
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method is provided for building improved calibration models or for improving modifications to these models or validation of the models used in the non-invasive spectroscopic measurement of an analyte or attribute of tissue. The method uses a matched reference sample and measurement of that sample to ensure that the correct relationship between the spectra and analyte is made during the model building, modification or calibration process. A matched reference sample is one in which the analyte of interest or attribute of interest in the reference sample is representative of the analyte or attribute at the site being non-invasively sampled or the agreement between the reference concentration and the non-invasively sampled concentration is clinically significant.