Method of treating tumors

US7029652B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• Merck Patent GmbH · DE

Inventors

• Siegfried Matzku · Wiesenbach, DE
• Patricia Burke · Lewisville, US
• Gerald L. DeNardo · El Macero, US
• Simon Goodman
• Sally J. DeNardo · El Macero, US

Key dates

• Filing date: Jul 31, 2002
• Grant date: Apr 18, 2006
• Expiry date: Mar 28, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.