Plasmodium falciparum AMA-1 protein and uses thereof
US7029685B2 · kind B2 · utility
29Cited by
1References
20Claims
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Key dates
| Filing date | Oct 15, 2002 |
| Grant date | Apr 18, 2006 |
| Priority date | — |
| Expiry date | Jan 29, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.