LPS-response gene compositions and methods
US7029861B1 · kind B1 · utility
6Cited by
16References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1999 |
| Grant date | Apr 18, 2006 |
| Priority date | — |
| Expiry date | Feb 22, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention describes a mutant TLR-4 in mice that does not recognize endotoxin and therefore does not stimulate the secretion of TNF from macrophages. Methods of detecting the mutation are provided; as are methods screening for drugs that may stimulate TNF production. Finally methods of incorporating and expressing the mutant TLR-4 genes into a host cell are contemplated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.