AFC1 and RCE1: isoprenylated CAAX processing enzymes
US7029911B1 · kind B1 · utility
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Key dates
| Filing date | Oct 2, 1998 |
| Grant date | Apr 18, 2006 |
| Priority date | — |
| Expiry date | Aug 2, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Two genes which encode polypeptides that mediate post-prenylation processing steps in CAAX polypeptides such as Ras are provided. The two genes (AFC1 and RCE1) encode polypeptides that mediate the removal of the AAX tripeptide from the CAAX polypeptide following prenylation. The genes and encoded polypeptides provide assays for testing compounds for an effect on post-prenylation processing steps. A heat shock assay for assessing Ras activity is also provided.
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