Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1

US7030135B2 · kind B2 · utility

Assignee

• Biovitrum AB · SE

Inventors

• Marianne Nilsson · Rimbo, SE
• Jerk Vallgarda · Uppsala, SE
• Tjeerd Barf · Ravenstein, NL

Key dates

• Filing date: May 22, 2001
• Grant date: Apr 18, 2006
• Expiry date: Jun 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C1-6-alkyl; E is a bond, —CH2— or —CO—; L is a bond, —CH2—, —CHR4— or —NR3—; R3 is H, C1-6-alkyl, C1-6-acyl or —COR4; R4 is morpholino or C1-6-amido; R6 and R7 are independently hydrogen or C1-6-alkyl; and R8 and R9 are independently hydrogen or C1-6-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.