Cell regulatory genes, encoded products, and uses related thereto
US7030227B1 · kind B1 · utility
1Cited by
2References
43Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 15, 1998 |
| Grant date | Apr 18, 2006 |
| Priority date | — |
| Expiry date | Oct 15, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.