Selective inhibition of aggrecanase in osteoarthritis treatment
US7030242B2 · kind B2 · utility
31Cited by
3References
3Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | May 3, 2005 |
| Grant date | Apr 18, 2006 |
| Priority date | — |
| Expiry date | May 23, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D241/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a method of treatment for osteoarthritis involving inhibitors of aggrecanase that demonstrate IC50s of less than 20 nM and demonstrate differential potency against matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs or reprolysins). This invention also relates to compounds, methods of treatment and composition of Formula I: or a therapeutically acceptable salt thereof, wherein
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.