Tetrahydroquinoline derivatives as stat6-modulators, preparation and use thereof

US7030246B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Håkan Bladh · Lund, SE
• Thomas Hansson · Lund, SE
• Grigorios Nikitidis · Lund, SE
• Carita Nordén · Lund, SE
• Lars Pettersson · Lund, SE
• Mikael Varga · Lund, SE

Key dates

• Filing date: Mar 26, 2002
• Grant date: Apr 18, 2006
• Expiry date: May 16, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) are modulators of STAT6 signal pathway activity, and can be used in the treatment of atopic dermatitis, urticaria, allergic asthma, allergic rhinitis, a food allergy, allergic conjunctivitis, hayfever, bullous pemphigoid, industrial sensitization, chronic rejection of transplants or COPD