Patent · US Expired

Method for the production of biperidin

US7030247B2 · kind B2 · utility

0Cited by

2References

11Claims

0Family size

Assignee

Abbott GmbH & Co. DG · DE

Inventors

Peter Klein · Itzehoe, DE
Marco Thyes
Markus Grosse · Schwetzingen, DE
Klaus Weber · Ludwigshafen, DE

Key dates

Filing date	May 17, 2002
Grant date	Apr 18, 2006
Priority date	—
Expiry date	May 20, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D295/108
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.