“Burst-free” sustained release poly-(lactide/glycolide) microspheres

US7033608B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Ramasubbu Jevanthi · Columbia, US
• John E. Van Hamont · Clarence, US
• Phil Friden · Bedford, US
• Robert H. Reid · Kensington, US
• F. Donald Roberts · Dover, US
• Charles E. McQueen · Olney, US
• Jean A. Setterstrom · Silver Spring, US

Key dates

• Filing date: Jun 22, 1999
• Grant date: Apr 25, 2006
• Expiry date: Jun 22, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5031
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1–100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.