Multi-parameter assays including analysis discs and methods relating thereto
US7033747B2 · kind B2 · utility
Assignees
Inventor
Key dates
| Filing date | Apr 11, 2002 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Apr 11, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/76
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and apparatus for testing a sample for target molecules or chemicals. The apparatus includes a rotatable optical disc having a reaction chamber and having at least two groups of beads or micro-particles, the different group of beads having at least two different densities, sizes, shapes, and/or color, and each bead in a group having different probes attached thereto. A sample is added to the reaction chamber and the disc is rotated. The reaction chamber has a density gradient medium that causes beads of different densities to remain at different radial locations, depending on the density of the beads. The beads are then inspected by directing a beam of electromagnetic radiation onto the disc. The beam may be reflected from or transmitted through the disc. The amount, or presence, or absence of targets is determined by analyzing the signal returned from the beam. Related methods of performing assays and making the disc apparatus are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.