Compositions and methods for nonenzymatic ligation of oligonucleotides and detection of genetic polymorphisms
US7033753B1 · kind B1 · utility
18Cited by
10References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 14, 2000 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Jan 14, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6827
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention is directed to novel compositions and methods for nonenzymatic ligation of oligonucleotides. In one aspect of the invention, the nonenzymatic ligation is selenium-mediated or tellurium mediated ligation. In another aspect, the invention provides for the use of fluorescence resonance energy transfer (FRET) to detect the nonenzymatic ligation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.