β-secretase and modulation of β-secretase activity
US7033812B2 · kind B2 · utility
2Cited by
7References
2Claims
0Family size
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Key dates
| Filing date | Dec 18, 2003 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Jan 4, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32–39 kDa or 22–26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5–7.0.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.