Activators of cyclin-dependent kinases
US7033816B1 · kind B1 · utility
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6Claims
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Key dates
| Filing date | Jul 19, 2002 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Mar 5, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4738
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A new gene family involved in cell cycle regulation was discovered. This family has been termed activators of cyclin-dependent kinases (ACDKs). A number of ACDK genes have been cloned and sequenced. Proteins encoded by ACDK genes specifically were shown to interact with CDKs and pRb, and to upregulate the kinase activity of a CDK using pRb as a substrate. Progression of a cell through the cell cycle can be regulated by modulating ACDK expression in the cell.
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