Methods for diagnosis and treatment of MDK1 signal transduction disorders
US7034112B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2002 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Jul 5, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to MDK1 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing.Methods for treatment, diagnosis, and screening are provided for diseases or conditions characterized by an abnormality in a signal transduction disorder. The signal transduction pathway involves an interaction between a MDK1 receptor tyrosine kinase and a receptor for the kinase. The MDK1 receptor tyrosine kinase may be truncated and lack a kinase domain and may be selected from the group consisting of MDK1.T1, MDK1.T2, MDK1.Δ1 and MDK1.Δ2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.