Packaging of positive-strand RNA virus replicon particles
US7034141B2 · kind B2 · utility
3Cited by
1References
37Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 28, 2001 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Oct 9, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention generally relates to recombinant polynucleotides, positive-strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.