Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins
US7034142B1 · kind B1 · utility
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8Claims
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Key dates
| Filing date | Mar 9, 2000 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Mar 9, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat shock response. This allows the development of greatly improved expression systems. The invention is also useful, for example, in the treatment of a patient suffering from a deficiency in the expression of a polypeptide and in the provision of vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.