Method of producing biperiden I

US7034158B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Gerhard Kastner · Ludwigshafen, DE
• Klaus Scheib · Schauernheim, DE

Key dates

• Filing date: May 17, 2002
• Grant date: Apr 25, 2006
• Expiry date: May 29, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/108
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing biperiden which is characterized in that an exo/endo mixture of 1-(bicyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is reacted with an isomer ratio of the exo form to the endo form of at least 2.5:1 with diphenyl magnesium, an isomer mixture containing biperiden is obtained therefrom and biperiden is produced therefrom.