Synthesis of pyrroles
US7034163B2 · kind B2 · utility
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Key dates
| Filing date | Sep 5, 2003 |
| Grant date | Apr 25, 2006 |
| Priority date | — |
| Expiry date | Sep 5, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1892
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved and highly efficient method for the preparation of 2-R(R=alkyl, aryl, H) pyrroles from nitrites (RCN, R=alkyl, aryl) is described using Lewis acid activated donor-acceptor cyclopropanes to react with aliphatic, aromatic, branched, α,β-unsaturated, or otherwise functionalized nitrites in a cascade [3+2] dipolar cycloaddition, dehydration and tautomerization sequence.
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