Non-human transgenic animals expressing platelet-derived growth factor C (PDGF-C) and uses thereof

US7034200B2 · kind B2 · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Ulf Eriksson
• Xuri Li · Stockholm, SE
• Annica Ponten · Stockholm, SE
• Karin Aase · Stockholm, SE
• Hong Li · Stockholm, SE

Key dates

• Filing date: Mar 28, 2001
• Grant date: Apr 25, 2006
• Expiry date: Mar 28, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C (PDGF-C) or an analog thereof, or a functional fragment of PDGF-C or analog thereof. These animals are useful for studying disease states characterized by overexpression of PDGF-C, as well as useful for evaluating therapies intended to treat such diseases.