Methods and compositions for identifying ligands for nuclear receptors
US7037656B2 · kind B2 · utility
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48Claims
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Key dates
| Filing date | Feb 20, 2001 |
| Grant date | May 2, 2006 |
| Priority date | — |
| Expiry date | Apr 25, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A yeast-based system and methods of use therefore are provided for identifying new molecules which activate nuclear receptors in a ligand-dependent fashion. In a preferred embodiment, a method is provided utilizing ecdysone receptor, USP and GRIP I encoding expression vectors which may be used to advantage for screening new and useful insecticidal compounds, detecting insecticidal residues as well as to regulate expression of a gene of interest in a host in a ligand-dependent manner.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.