Method for generating influenza viruses and vaccines
US7037707B2 · kind B2 · utility
81Cited by
8References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 4, 2003 |
| Grant date | May 2, 2006 |
| Priority date | — |
| Expiry date | Apr 17, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on the discovery that a high titer reassortant influenza virus is produced in mammalian cell culture by replacing the NS gene of the A/PuertoRico/3/24 master strain with the NS gene of the A/England/1/53 strain. The invention provides influenza viruses and vaccines generated in mammalian cells as well as methods for producing such. The invention further provides an influenza virus master strain and kits for generating reassortant influenza viruses in mammalian cell culture and methods of making and using the master strain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.