Composition and method for treating graft-versus-host disease
US7037900B2 · kind B2 · utility
3Cited by
6References
39Claims
0Family size
Assignee
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Key dates
| Filing date | Oct 12, 2001 |
| Grant date | May 2, 2006 |
| Priority date | — |
| Expiry date | Oct 12, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.