Bicyclo 4.4.0 antiviral derivatives

US7037913B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Tao Wang · Farmington, US
• Owen Brendan Wallace · Zionsville, US
• Nicholas A. Meanwell · East Hampton, US
• John F. Kadow · Wallingford, US
• Zhongxing Zhang · Wallingford, US
• Zhong Yang · Middletown, US

Key dates

• Filing date: Mar 20, 2003
• Grant date: May 2, 2006
• Expiry date: Jul 22, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/205
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds of Formula I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. A is selected from the group consisting of C1-6alkoxy, C1-6alkyl, C3-7cycloalkyl, phenyl, and heteroaryl; wherein said heteroaryl may be monocyclic or bicyclic and may be comprised of three to eleven atoms selected from the group consisting of C, N, NR9, O, and S, and wherein each ring of said phenyl and heteroaryl is optionally substituted with one to five same or different substituents selected from the group consisting of R19–R23;W is O or —NH;T is Z1 is CR1 or N;Z2 is CR2 or N;Z3 is CR3 or N;Z4 is CR4 or N;Z5 is CR5 or N;Z6 is CR6 or N;Z7 is CR7 or N;Z8 is CR8 or N.