Patent · US Expired

Pyrimidine derivatives as IL-8 receptor antagonists

US7037916B2 · kind B2 · utility

3Cited by

3References

33Claims

0Family size

Assignee

Pharmacopeia Drug Discovery, Inc. · US

Inventors

Shawn David Erickson · Leonia, US
John J. Baldwin · Gwynedd Valley, US
Roland E. Dolle · King of Prussia, US
James Inglese
Michael H. J. Ohlmeyer · Plainsboro, US
Koc-Kan Ho · Mount Kisco, US
Adolph C. Bohnstedt · Burlington, US
Steven G. Kultgen · Hillsborough Township, US
Paolo Conti · Firenze, IT
Dirk Leysen · Diepenbeek, BE
Jaap Van Der Louw · Oss, NL

Key dates

Filing date	Jan 10, 2003
Grant date	May 2, 2006
Priority date	—
Expiry date	Dec 2, 2023

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D405/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.