Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US7038016B2 · kind B2 · utility
8Cited by
16References
8Claims
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Key dates
| Filing date | Aug 21, 2001 |
| Grant date | May 2, 2006 |
| Priority date | — |
| Expiry date | Mar 1, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/962
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention employs a dissolved activated polyethylene glycol (aPEG) or related molecule that has been passed through a filtration means for the substantial reduction of bioburden or endotoxin levels in the aPEG solution. The resulting filtered aPEG solution can be used for the preparation of a PEGylated hemoglobin solution containing substantially reduced levels of bioburden or endotoxin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.