Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia
US7041046B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 7, 2001 |
| Grant date | May 9, 2006 |
| Priority date | — |
| Expiry date | Feb 24, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N2005/1004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides improved devices, methods, and kits for inhibiting restenosis and hyperplasia after intravascular intervention. In particular, the present invention provides controlled immunomodulator delivery in combination with ionizing radiation to selected locations within a patient's vasculature to reduce and/or inhibit restenosis and hyperplasia rates with increased efficacy. In one embodiment, the combination radiation and immunomodulator delivery catheter for inhibiting hyperplasia comprises a catheter body having a proximal end and distal end, an ionizing radiation source coupleable to the catheter body for applying a radiation dose to a body lumen, and a porous material, matrix, membrane, barrier, coating, infusion lumen, stent, graft, or reservoir for releasing an immunomodulator to the body lumen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.