Process for making ondansetron and intermediates thereof
US7041834B2 · kind B2 · utility
1Cited by
1References
30Claims
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Assignee
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Key dates
| Filing date | Jan 23, 2004 |
| Grant date | May 9, 2006 |
| Priority date | — |
| Expiry date | Jan 23, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process useful for making ondansetron that comprises reacting a carbazolone in a reaction mixture comprising a carbazolone of formula (2), a formaldehyde or precursor thereof, and an amine of formula (3) in a non-aqueous polar solvent and in the presence of a water binding agent. The reaction product(s) can be reacted with an amine of formula (5) to form ondansetron. The water binding agent can improve the yield and/or speed of the reaction
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.