Fluorinated phenyl thiophenyl derivatives and their use for imaging serotonin transporters

US7041851B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Hank F. Kung · Lansdowne, US
• Chyng-Yann Shiue · East Setauket, US
• Shunichi Oya · Princeton Junction, US
• Seok Rye Choi · Chester, US
• Grace G. Shiue · Villanova, US
• Ping Fang · Drexel Hill, US

Key dates

• Filing date: Mar 14, 2003
• Grant date: May 9, 2006
• Expiry date: Jun 4, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to novel fluorinated phenyl thiphenyl (also named diarylsulfide) derivatives and their use in Positron Emission Tomagraphy (PET) imaging of Serotonin Transporters (SERTS). The present invention also provides diagnostic compositions comprising the novel compounds of the present invention, and a pharmaceutically acceptable carrier or diluent. The invention further provides a method of imaging SERTS, comprising introducing into a patient a detectable quantity of a labeled compound of the present invetion, or a pharmaceutically acceptable salt, ester, amide or prodrug thereof.