Transgenic luciferase mouse
US7041869B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 3, 2003 |
| Grant date | May 9, 2006 |
| Priority date | — |
| Expiry date | Oct 3, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/007
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides a transgenic animal expressing the reporter gene, luciferase, driven by a promoter (e.g. the E2F1 promoter) that acts as a sensor of cell cycle. The luciferase substrate, luciferin, emits light when metabolized, and the light is transmitted through mammalian tissues. Therefore, the transgenic animal model of the present invention allows for monitoring of areas of major cell cycle activity, a characteristic of cancer cells, under adequate visualization conditions. These transgenic animals are useful as in vivo models for testing preventative measures for cancer as well as for testing novel therapeutic modalities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.