Prevention of regression in thermal ciliary muscle tendinoplasty
US7044945B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Mar 26, 2003 |
| Grant date | May 16, 2006 |
| Priority date | — |
| Expiry date | Jan 12, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2009/00895
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Methods and apparatus are provided that prevent or inhibit functional regression caused by the stromal remodeling resulting from epithelial or fibroblastic apoptosis or necrosis in patients who will undergo or have undergone a thermal ciliary muscle tendinoplasty or scleral collagen shrinkage procedures. Methods and compositions are provided that prevent apoptosis in epithelial cells by stromal cooling during thermal tendinoplasty procedures; that create or restore stabilizing molecular cross-links between scleral stromal lamellar fibers; and that interrupt at least one step in the stromal remodeling response including inhibition of apoptosis, fibroblastic proliferation and migration, and inhibition of collagenesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.