Whole cell assay systems for cell surface proteases
US7045311B2 · kind B2 · utility
15Cited by
54References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 25, 2002 |
| Grant date | May 16, 2006 |
| Priority date | — |
| Expiry date | Feb 14, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The activity of a cell surface protease, particularly an ADAM, is determined in a rapid and sensitive assay employing a whole cell system. The assays are effective to identify effector molecules that affect the activity of a cell surface protease directly or indirectly, and to screen for therapeutic agents that modulate those effector molecules. The assays can also be used to screen for therapeutic agents that modulate the activity of a cell surface protease associated with a disease or medical condition. Kits comprising at least one component of the present assays are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.