ACE-2 modulating compounds and methods of use thereof

US7045532B2 · kind B2 · utility

Assignee

• Millennium Pharmaceuticals, Inc. · US

Inventors

• Susan Acton · Lexington, US
• Timothy D. Ocain · Framingham, US
• Alexandra E. Gould · Cambridge, US
• Natalie Dales · Arlington, US
• Bing Guan · Needham, US
• James Brown · Moorpark, US
• Michael A. Patane · Harleysville, US
• Vivek Kadambi · Singarayakonda, IN
• Michael Solomon · Concord, US
• Alain Stricker-Krongrad · Lexington, US

Key dates

• Filing date: Oct 31, 2001
• Grant date: May 16, 2006
• Expiry date: Aug 29, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I):Z-Λ  (I)Wherein Z is a zinc coordinating moiety and Λ is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.