2-(pyrazol-3-yl)carbapenem derivatives
US7045619B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2002 |
| Grant date | May 16, 2006 |
| Priority date | — |
| Expiry date | Jun 3, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (I): whereinRα is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl;Rβ is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; orRα and Rβ together form an optionally substituted 5 or 6 membered heterocyclic ring with or without additional heteroatoms;R1 is (C1-6)alkyl which is unsubstituted or substituted by fluoro, a hydroxy group which is optionally protected by a removable hydroxy protecting group, or by an amino group which is optionally protected by a removable amino protecting group;R2 is hydrogen or methyl; and—CO2R3 is carboxy or a carboxylate anion or the group R3 is a removable carboxy protecting group. This invention also relates to processes for its preparation, intermediates and pharmaceutical compositions comprising compounds of formula (I). Compounds of formula (I) which include pharmaceutically acceptable salts or pharmaceutically acceptable in vivo hydrolysable esters thereof have a broad spectrum of anti-bacterial activity and show good stability towards DHP-1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.