Method for producing-2[-5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane

US7045629B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Heinz-Hermann Bokel · Darmstadt, DE
• Steffen Neuenfeld · Messel, DE
• Ludwig Gantzert · Pfungstadt, DE
• Ralf Knierieme · Groß-Zimmern, DE
• Elke Simon · Groß-Zimmern, DE
• Ralf Devant · Darmstadt, DE
• Udo Helm · Michelstadt, DE
• Helmut Reubold · Annaberg-Buchholz, DE

Key dates

• Filing date: Apr 8, 2002
• Grant date: May 16, 2006
• Expiry date: May 6, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, the enantiomers and its salts, characterised in that 5-(4-fluorophenyl)pyridine-3-carbaldehyde is reacted directly with aminomethylchroman or its salts under reducing conditions to give 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman, and the latter is, if desired, converted into one of its physiologically acceptable salts by treatment with an acid.