Diagnosis and treatment of myocardial failure
US7049066B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 1, 2001 |
| Grant date | May 23, 2006 |
| Priority date | — |
| Expiry date | Jan 24, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart. In one embodiment, the expression of α-myosin heavy chain, β-myosin heavy chain, or both, are quantitated and their expression levels compared to that seen normal human ventricular myocardial tissues. In another embodiment, the expression of α1-thyroid hormone receptor, α2-thyroid hormone receptor, a α1-thyroid hormone receptor+β1-thyroid hormone receptor, or combinations thereof, are quantitated, and their expression levels compared to that seen normal human ventricular myocardial tissues. Therapeutic interventions based on altering the expression of the aforementioned genes also are provide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.