Modulation of hedgehog-mediated signaling pathway
US7049090B2 · kind B2 · utility
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4References
7Claims
0Family size
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Key dates
| Filing date | Oct 1, 2003 |
| Grant date | May 23, 2006 |
| Priority date | — |
| Expiry date | Oct 1, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.