Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US7049100B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Mar 22, 2002 |
| Grant date | May 23, 2006 |
| Priority date | — |
| Expiry date | Dec 23, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A multiple-plasmid system for heterologous expression of polyketides facilitates combinatorial biosynthesis. The method can be extended to any modular polyketide synthase (PKS) or non-ribosomal peptide synthase (NRPS) and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS or NRPS products by tailoring enzymes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.