Process for the production of L-amino acids by fermentation using coryneform bacteria with an attenuated mqo gene

US7049106B2 · kind B2 · utility

Assignee

• Degussa AG · DE

Inventors

• Mike Farwick · Essen, DE
• Brigitte Bathe · Salzkotten, DE
• Thomas Hermann · Bielefeld, DE
• Achim Marx · Bielefeld, DE
• Walter Pfefferle · Bodenwerder, DE

Key dates

• Filing date: Apr 9, 2002
• Grant date: May 23, 2006
• Expiry date: Feb 26, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.