Labelled glutamine and lysine analogues
US7049289B1 · kind B1 · utility
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10Claims
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Key dates
| Filing date | May 14, 1999 |
| Grant date | May 23, 2006 |
| Priority date | — |
| Expiry date | May 14, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.