Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
US7049406B2 · kind B2 · utility
45Cited by
17References
6Claims
0Family size
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Key dates
| Filing date | Mar 27, 2002 |
| Grant date | May 23, 2006 |
| Priority date | — |
| Expiry date | Apr 8, 2023 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.