Methods and reagents for tissue engineering of cartilage in vitro

US7052514B2 · kind B2 · utility

Assignee

• Curis, Inc. · US

Inventors

• Karin Kellner · Regensburg, DE
• Kurt Lang · Penzberg, DE
• Apollon Papadimitriou · Bichl, DE
• Ulrike Leser-Reiff · Penzberg, DE
• Michaela Schultz · Regensburg, DE
• Torsten Blunk · Bad Abbach, DE
• Achim Goepferich · Sinzing, DE

Key dates

• Filing date: Apr 27, 2001
• Grant date: May 30, 2006
• Expiry date: Dec 28, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/06
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention makes available an optimal concentration of a hedgehog polypeptide for modulating growth and/or cartilage production by chondrocytes. The present invention allows for improvements in the culturing of chondrocytes to develop cartilaginous tissue ex vivo suitable for implantation to replace damaged or deteriorated cartilage in a patient.