Process for the production of L-amino acids using strains of the family Enterobacteriaceae that contain an attenuated fruR gene

US7052883B2 · kind B2 · utility

Assignee

• Degussa AG · DE

Inventors

• Mechthild Rieping · Bielefeld, DE
• Thomas Hermann · Bielefeld, DE

Key dates

• Filing date: Apr 3, 2002
• Grant date: May 30, 2006
• Expiry date: Jan 27, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a process for producing an L-amino acid, in particular, L-threonine, which comprises: cultivating a microorganism of the family Enterobacteriaceae producing the desired L-amino acid under conditions suitable for production of the amino acid, in which the fruR (cra) (fructose repressor) gene or nucleotide secluences coding therefor in the microorganism is attenuated, in particular are switched off or eliminated, and recovering the L-amino acid from the medium or in the cells of the microorganism.