Succinoylamino benzodiazepines as inhibitors of Aβ protein production
US7053084B1 · kind B1 · utility
15Cited by
31References
56Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 17, 2000 |
| Grant date | May 30, 2006 |
| Priority date | — |
| Expiry date | Feb 17, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel lactams having the formula (I):to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.