Vanilloid receptor ligands and their use in treatments

US7053088B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Elizabeth M. Doherty · Thousand Oaks, US
• Jiawang Zhu · Simi Valley, US
• Markian Stec · Thousand Oaks, US
• Mark H. Norman · Thousand Oaks, US
• Vassil I. Ognyanov · Thousand Oaks, US
• Christopher H. Fotsch · Thousand Oaks, US
• Ning Chen · Thousand Oaks, US
• Partha Chakrabarti · Simi Valley, US
• Liping H. Pettus · Thousand Oaks, US
• Hui-Ling Wang · Thousand Oaks, US
• Xianghong Wang · Dublin, US
• Premilla Arasasingham · Thousand Oaks, US

Key dates

• Filing date: May 20, 2003
• Grant date: May 30, 2006
• Expiry date: Jun 20, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the general structureand compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.