Compositions and methods for treating heart failure

US7053094B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Fady Malik · Burlingame, US
• Adam Lewis Tomasi · San Francisco, US
• Bainian Feng · Foster City, US
• Erica Anne Kraynack · South San Francisco, US
• Kathleen Ann Elias · San Francisco, US
• Pu-Ping Lu · Foster City, US
• Whitney W. Smith · South San Francisco, US
• Xiangping Qian · Foster City, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Jan 20, 2005
• Grant date: May 30, 2006
• Expiry date: Jan 20, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain substituted benzamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.