Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives
US7053113B2 · kind B2 · utility
1Cited by
26References
8Claims
0Family size
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Key dates
| Filing date | Dec 24, 2003 |
| Grant date | May 30, 2006 |
| Priority date | — |
| Expiry date | Mar 3, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65583
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.