Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related methods
US7053177B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 15, 1998 |
| Grant date | May 30, 2006 |
| Priority date | — |
| Expiry date | May 15, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6937
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastrointestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.